For men, low testosterone means high risk of severe COVID-19 For men, low testosterone means high risk of severe COVID-19 In addition to issues relating to the reliability of compounded products themselves, appropriate clinical studies on pharmacokinetics are lacking. As such, even if consistent testosterone levels could be achieved, providers issuing prescriptions for compounded testosterone need to consider performing additional monitoring and dose adjustments to ensure appropriate therapeutic levels. There are limited data in men on active surveillance who are candidates for testosterone therapy. In some cases, the etiology is obvious (e.g., iatrogenic causes), in others, a karyotype may be warranted to establish a diagnosis of KS (47, XXY).169 In other cases, it may not be possible to establish a definitive etiology. The categorization of evidence strength is conceptually distinct from the quality of individual studies. The Panel explicitly uses the term testosterone therapy rather than testosterone replacement therapy or testosterone supplementation to be in keeping with the beliefs of the current thought leaders in the field. Many testosterone formulations are available (Table 459,60 ), and no formulation has superior clinical effects. The selection of formulation requires discussion about administration route, adverse effects, and cost. Testosterone preparations are FDA Schedule III controlled substances that are subject to diversion and misuse. Several at-home collection test kits for checking testosterone levels are available without a prescription. These test kits may be sold at your local pharmacy and are available online. Treatments can depend on the cause of elevated testosterone levels. A 2022 analysis found that free testosterone may have links with prostate cancer, including early onset prostate cancer and aggressive prostate cancer. Read on to learn more about the signs and symptoms of high testosterone in males, when to contact a doctor, and more. Men’s health topics are important to discuss with a doctor, but for many men it is difficult to have these conversations with their health care provider. For example, a 50-year-old man with testosterone levels of 8.5 nmol/l but no symptoms would unlikely benefit from treatment, even though his levels are outside the normal range. And often, switching to a healthier lifestyle is enough to improve testosterone levels naturally. The lower the levels of testosterone, the more severe the disease. For example, those with the lowest levels of testosterone in the blood were at highest risk of going on a ventilator, needing intensive care or dying. A disruption in the pituitary gland can also impact the adrenal gland. Addison’s disease or adrenal insufficiency is a hormonal condition that occurs due to underactive adrenal glands and can cause a low level of its hormones. Often, the symptoms of low testosterone in women are undiagnosed or misdiagnosed. Some of the conditions that low testosterone may be mistaken for include stress, depression and the side effects of menopausal changes in women. Low testosterone over a long period may also contribute to long-term health conditions such as heart disease, memory issues and loss of bone density. Excessive alcohol consumption may increase levels of testosterone in